Cost-Effectiveness Analysis: Risk Stratification of Nonalcoholic Fatty Liver Disease (NAFLD) by the Primary Care Physician Using the NAFLD Fibrosis Score

The BARD score and the NAFLD fibrosis score in the assessment of advanced liver fibrosis in nonalcoholic fatty liver disease

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) refers to a very wide clinical spectrum. Advanced fibrosis that accompanies disease leads to the development of cirrhosis and hepatocellular carcinoma. Thus, identification of patients with advanced fibrosis is essential. The aim of the present study was to compare the usefulness of NAFLD fibrosis and BARD scores in predicting fibrosis in NAF...

Pharmacological options for the nonalcoholic fatty liver disease (NAFLD)

Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD)

BACKGROUND The prevalence of nonalcoholic fatty liver disease (NAFLD) has significantly increased over the last decades. Despite existence of several interventions, there remains unclear which interventions work the best. METHODS A systematic review and network meta-analysis of randomized trials comparing efficacy of all treatment options in NAFLD were performed to determine comparative effic...

Effect of Ramadan fasting on alanine transferase (ALT) in nonalcoholic fatty liver disease (NAFLD)

Background: The effects of Ramadan fasting on NAFLD are unknown and there are very limited studies have done in this area. Some nutritional and behavioral changes of fasting people in Ramadan can affect NAFLD. These include nutrition with high fat and calories, altering in weight and sleep and low physical activity. We decided to evaluate the effects of these changes on one of the important ind...

Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD)

Genetics and epigenetics play a key role in the development of several diseases, including nonalcoholic fatty liver disease (NAFLD). Family studies demonstrate that first degree relatives of patients with NAFLD are at a much higher risk of the disease than the general population. The development of the Genome Wide Association Study (GWAS) technology has allowed the identification of numerous ge...